Philosophy Image
Mission Statement

INSTINCT BROTHERS HOLDINGS focuses on the manufacturing and sales of stem cell-based cosmetics, expanding its business in the regenerative medicine field. We provide comprehensive regenerative medicine services, leveraging our research expertise to improve beauty, health, and lifestyle habits.
We are committed to delivering high-quality results and contributing to society through consistent, reliable services.

Our mission is to "Bring joy to everyone in the world! Build a company that contributes to society!" Through our medical, beauty, and health-related businesses, we aim to extend the healthy lifespan of society. We strive to deliver the greatest joy, spread Japan's regenerative medicine technology and services globally, and contribute to the advancement of the regenerative medicine industry. Our goal is to create a future where everyone can enjoy a healthy life.

Corporate Mission

Our company was built on the expertise, techniques, and sales methods that our current Chairman and CEO, Tomoki Nagano, has developed over years in the cosmetics industry, establishing our manufacturing, sales, and branding.

In Japan, under the Pharmaceutical and Medical Device Act (PMD Act), only pharmaceuticals and quasi-drugs are allowed to claim effects and efficacy. Cosmetics, by law, are not permitted to have noticeable effects. We have conducted extensive research to understand why users often donʼt feel results or see benefits from cosmetics.

Our findings revealed that most cosmetics contain very small amounts of active ingredients, with 80-95% of the product being primarily water.

From there, we analyzed other companies' products and gained insight into the threshold for ingredients: those included above 1% and those present below 1%.

Under Japan's Pharmaceutical and Medical Device Act (PMD Act), manufacturers and distributors are required to list ingredients on cosmetic products.

Ingredients present at less than 1% can be listed in any order. These trace ingredients, making up less than 1%, are generally considered to have little impact on the productʼs overall effectiveness. We discovered that many products list a large number of ingredients below the 1% threshold, though most are likely present in negligible amounts.

Cosmetics can be categorized into three areas: moisturizing, whitening, and anti-aging. We chose to focus on anti-aging. While there are potential solutions for moisturizing and whitening, anti-aging presents a more complex challenge. As humans, we naturally oxidize as we breathe, and we cannot escape the effects of gravity, which leads to sagging skin. Additionally, lifestyle habits and climate changes cause more wrinkles and spots, making anti-aging a critical area for concentrated efforts.

This journey led us to discover the power of human stem cell culture fluid. Human stem cells are extracted from sources like umbilical cord blood, fat, spinal cord, and dental pulp. Depending on the extraction method, these stem cells are used in pharmaceuticals, while the culture fluid is used as a cosmetic ingredient.

Stem cell culture fluid does not contain stem cells themselves, but it has been confirmed to contain many cytokines and growth factors. By using the stem cell culture fluid produced by INVITRX, a U.S.-based company, as a cosmetic ingredient, numerous results have been reported, such as "improved skin condition", "reduced acne", "smoother skin", "longer eyelashes", "disappearing dark spots", and "brighter skin tone". We have entered an exclusive distribution agreement with INVITRX for the use of their stem cell culture fluid in cosmetics in Japan.

Combining INVITRXʼs regenerative medicine technology with our advanced manufacturing techniques, we developed a unique approach called Adult Cell Programming.

Our cosmetics containing stem cell culture fluid are designed with the concept: "Your skin can regenerate and grow again! Find the right cosmetics for yourself once more!" We continue to research, plan, and develop safe, reliable products to offer to our customers.

  1. We will establish a solid business foundation for cosmetics made from regenerative medicine stem cell culture fluid.
  2. Leveraging strong relationships with our partners, we will enhance the development of Japanese stem cell culture fluid while maintaining high price competitiveness as a raw material supplier, ensuring quality, safety, and reliability.
  3. We will also utilize partnerships with other companies to sustain quality in pricing, effectiveness, and efficacy.
  4. Investing in talent is our top priority, so we will actively recruit, emphasizing teamwork in our hiring processes.
  5. To avoid excessive credit risk, we will conduct credit investigations and manage credit for our trading partners.
  6. Managing legal risks associated with the Pharmaceutical and Medical Device Act, the Act Against Unjustifiable Premiums and Misleading Representations, and the Anti-Monopoly Act is fundamental to our operations. We will establish a compliance committee within the company under the guidance of dedicated staff and external advisors.
  7. We will proactively engage in new business initiatives while understanding both offensive and defensive strategies:
    (a) We will work to use stem cell conditioned media as a therapeutic product in clinics.
    (b) We will enhance research and development for DNA reprogramming products.
    (c) We will obtain licenses for Type II and Type III regenerative medicine at partner clinics and focus on developing treatments for major diseases and lifestyle-related conditions.

Our management strategy is as follows:

Regenerative
Medicine

幹細胞培養化粧品にお ける新たな効果、効能 ある製品の開発

Treatment
Expansion

再生医療関連事業に おける、新たな治療の 拡大

Sales
Enhancement

各子会社、協業会社と の連携により、営業力 の強化

Business
Development

再生医療関連事業によ り蓄積されたデータ 、 自社ブランドのAIデ ータを活用したノウハ ウを生かした、新たな 事業展開

Global
Outreach

日本技術、安心、安 全 、おもてなしを活用 し、日本国内外に医 療、健康、美容の技術 を発信

  • Cosmetics OEM/ODM Marketing
    We work with notable brands like BROSKY, peau de bebe, aesthetic salons, brand holders, and other companies.
  • ISB Own Brand
  • Regenerative Medicine
    Regenerative medicine support
    Genrever Clinic / Stem cell supernatant, exosomes,
    Operation of stem cell culture facility (CPC)
    Differentiation strategy by introducing new technology / Business alliance
    Quantum optimization technology (FINE TIUNING)
    Epigenetics technology (cell reprogramming)
    Drug discovery for AGA/FAGA treatment
    Overseas business / Business alliance
    Indonesia / PT Royal Prima
    Malaysia / Cell101 International Sdn Bhd & AS Clinic
    • Our core business, cosmetics OEM, involves researching and developing exclusive raw materials and unique formulations.
    • The background to the development is to bring joy to everyone around the world in accordance with our corporate mission!
      In order to bring smiles to everyone, we developed a formula that can be felt, even though regular cosmetics should not be effective.
    • As a result, many clients share their joy through before-and-after testimonials, allowing us to continuously improve our products.
    • We have partnered with influencers to sell our own cosmetics brand to the influencers' followers (= assets).
    • In August 2023, we launched our original brand, GENREVER, and opened a flagship store in Harajuku, Tokyo.
    • We are expanding our membership base by leveraging the advantages of in-house research and manufacturing.